Manchester City went head-to-head with the Red Devils in a crucial derby to keep their title hopes alive.
And the Portuguese midfielder provided the breakthrough in the second-half with a brilliant finish.
After receiving the ball from Ilkay Gundogan, Silva shot the ball with his left foot from the right flank, beating David De Gea.
The Citizens wrapped up the game 2-0 with another goal from winger Leroy Sane.
Silva has now scored 11 goals and provided 7 assists this season across all competitions.
The former Monaco Player has been one of the key players for Pep Guardiola in the quest for Premier League glory this season.
With this win, the Citizens have once again reached the top of the table, a point ahead of their title-chasing rivals Liverpool.
Guardiola and his men were left disappointed, following their shocking exit from the Champions League.
However, the Spaniard is confident of winning the League title along with FA Cup glory.
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They will play Wolves in the FA Cup final next month.